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KMID : 1094020120290040297
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Journal of Veterinary Clinics
2012 Volume.29 No. 4 p.297 ~ p.300
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Effects of Open versus Laparoscopic Cholecystectomy on Oxidative Stress in Dogs
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Lee Jae-Yeon
Jeong Seong-Mok
Kim Myung-Cheol
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Abstract
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In the present study, we investigated and compared the oxidant-antioxidant status of dogs undergoing open and laparoscopic cholecystectomy. Ten male beagle dogs, 4-6 years old, weighing 7-12 kg were used. The animals were randomly assigned to one of two groups according to the type of surgical procedure; open (group 1, n = 5) or laparoscopic cholecystectomy (group 2, n = 5). Heart rate, mean arterial pressure, end-tidal carbon dioxide, peripheral oxygen saturation, and respiratory rates were measured. Plasma total oxidant status (TOS) and total antioxidant status (TAS) levels for the evaluation of oxidative stress were measured. The ratio of the TOS to the TAS gave oxidative stress index (OSI), which is an indicator of the degree of oxidative stress. TOS, OSI and TAS levels were significantly changed after surgery in comparison to levels of before anesthesia. There were no significant different between groups. In the present study, we showed that oxidative stress parameters were found similar in dogs underwent laparoscopic or open cholecystectomy.
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KEYWORD
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cholecystectomy, laparoscopic surgery, oxidative stress, dogs
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